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The perform of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which plays a vital regulatory purpose in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also promote cancer